16 top research links supporting the use of High-Dose Vitamin C for COVID-19 Patients

Research
Written By Guest User

We are maintaining a list of research and consensus articles on the potential for IV Vitamin C therapy to be a supportive treatment for COVID-19 patients.

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  1. Shanghai 2019 comprehensive treatment of coronavirus disease expert consensus: Expert Group on Clinical Treatment of New Coronary Virus Disease in Shanghai. China Journal of Infectious Diseases, 2020,38: Online Prepublish. DOI: 10.3760/cma.j.issn.1000-6680.2020.0016 in Chinese http://rs.yiigle.com/yufabiao/1183266.htm and also referenced in English http://orthomolecular.activehosted.com/index.php?action=social&chash=0a09c8844ba8f0936c20bd791130d6b6.148&s=627630fc46495e9c2b490d93b5f9ceac

  2. Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia: a Prospective Randomized Clinical Trial. ZhiYong Peng, Zhongnan Hospital, Feb 14, 2020. https://clinicaltrials.gov/ct2/show/NCT04264533

  3. Can early and high intravenous dose of vitamin C prevent and treat coronavirus disease 2019 (COVID-19)? Richard Z Cheng. https://doi.org/10.1016/j.medidd.2020.100028

  4. Three U.S. hospitals use IVs of Vitamin C and other low-cost, readily available drugs to cut the death-rate of COVID-19 — without ventilators! https://isom.ca/wp-content/uploads/2020/03/Treating-Covid-19-in-ER-2-March-30-1.pdf

  5. Hemilä, H., Chalker, E. Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a meta-regression analysis. j intensive care 8, 15 (2020). https://doi.org/10.1186/s40560-020-0432-y

  6.  Integrative Oncology Outcomes Study in Breast Cancer (IO-OS-BC) ClinicalTrials.gov Identifier: NCT01366248 

  7. Padayatty SJ, Sun AY, Chen Q, Espey MG, Drisko J, Levine M. Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects. PLoS One. 2010;5(7):e11414. Published 2010 Jul 7. doi:10.1371/journal.pone.0011414 

  8. Mikirova N, Casciari J, Rogers A, Taylor P. Effect of high-dose intravenous vitamin C on inflammation in cancer patients. J Transl Med. 2012;10:189. Published 2012 Sep 11. doi:10.1186/1479-5876-10-189 

  9. Mikirova N, Casciari J, Riordan N, Hunninghake R. Clinical experience with intravenous administration of ascorbic acid: achievable levels in blood for different states of inflammation and disease in cancer patients. J Transl Med. 2013;11:191. Published 2013 Aug 15. doi:10.1186/1479-5876-11-191 

  10. Hoffer LJ, Robitaille L, Zakarian R, et al. High-dose intravenous vitamin C combined with cytotoxic chemotherapy in patients with advanced cancer: a phase I-II clinical trial. PLoS One. 2015;10(4):e0120228. Published 2015 Apr 

  11. doi:10.1371/journal.pone.0120228 7. Duconge J, Miranda-Massari JR, Gonzalez MJ, Jackson JA, Warnock W, Riordan NH. Pharmacokinetics of vitamin C: insights into the oral and intravenous administration of ascorbate. P R Health Sci J. 2008 Mar;27(1):7-19. PMID: 18450228 

  12. Ried K, Travica N, Sali A. The acute effect of high-dose intravenous vitamin C and other nutrients on blood pressure: a cohort study. Blood Press Monit. 2016;21(3):160–167. doi:10.1097/MBP.0000000000000178

  13. Joseph Quinn, Bryan Gerber, Ryan Fouche, Katharine Kenyon,Zachary Blom, and Purushothaman Muthukanagaraj Effect of High-Dose Vitamin C Infusion in a Glucose-6-Phosphate Dehydrogenase-Deficient Patients Case Reports in Medicine. Hindawi 2017/11/26 https://doi.org/10.1155/2017/5202606.

  14. Prier M, Carr AC, Baillie N. No Reported Renal Stones with Intravenous Vitamin C Administration: A Prospective Case Series Study. Antioxidants (Basel). 2018;7(5):68. Published 2018 May 21. doi:10.3390/antiox7050068  

  15. Robitaille L, Mamer OA, Miller WH Jr, et al. Oxalic acid excretion after intravenous ascorbic acid administration. Metabolism. 2009;58(2):263–269. doi:10.1016/j.metabol.2008.09.023  

  16. Lawton JM, Conway LT, Crosson JT, Smith CL, Abraham PA. Acute oxalate nephropathy after massive ascorbic acid administration. Arch Intern Med. 1985;145(5):950–951.  

  17. Bazzan AJ, Zabrecky G, Wintering N, Newberg AB, Monti DA. Retrospective Evaluation of Clinical Experience With Intravenous Ascorbic Acid in Patients With Cancer. Integr Cancer Ther. 2018;17(3):912–920. doi:10.1177/1534735418775809

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